Her great-great-grandfather was once President Andrew Jackson’s doctor.
She won the Best Actress Academy Award for playing obsessed fan Annie Wilkes in Misery, the 1990 film version of the Stephen King novel. On the road, some people don't have any idea who I am; they just see some old woman doddering around.
She was very much praised by her work in Fifth of July, Come Back to the Five and Dime and Jimmy Dean.
She also has successful New York stage productions such as Frankie and Johnny in the Clair de Lune and Off Broadway.
She also appeared in ten episodes of Six feet Under.