But by weakening the body’s immune system, these drugs increase the chance that someone infected with KSHV (Kaposi sarcoma associated herpesvirus) will develop KS.
When HIV damages the immune system, people who also are infected with a certain virus (the Kaposi sarcoma associated herpesvirus or KSHV) are more likely to develop KS. This means that when KS occurs in someone infected with HIV, that person officially has AIDS (and is not just HIV-positive).
In the United States, treating HIV infection with highly active antiretroviral therapy (HAART) has resulted in fewer cases of epidemic KS.
Other factors in Africa that weaken the immune system (such as malaria, other chronic infections, and malnutrition) also probably contribute to the development of KS, since the disease affects a broader group of people that includes children and women.
Endemic KS tends to occur in younger people (usually under age 40).
Endemic KS used to be the most common type of KS in Africa.